The Medicines Company declares positive results from Inclisiran trial
Category: #health  By Nikita Chaurasia  Date: 2019-08-28
  • share
  • Twitter
  • Facebook
  • LinkedIn

The Medicines Company declares positive results from Inclisiran trial
  • The ORION-11 trial of inclisiran sodium 300 mg reached all secondary and primary endpoints with efficacy that is consistent with the findings from Phase 2 and 1 trials.
     
  • The trial evaluated that inclisiran was tolerated well and confirmed that its safety profile was as favorable as that shown in the ORION-3 and ORION-1 Phase 2 open-label extension studies.

The Medicines Company, a biopharmaceutical company dedicated to halt atherosclerosis progression and reduce cardiovascular risk, reportedly announced the positive topline outcomes of the first Phase 3 clinical trial examining the safety, tolerability and efficacy of inclisiran to reduce LDL-cholesterol by taking doses twice a year.

The ORION-11 trial of inclisiran sodium 300 mg reached all secondary and primary endpoints with efficacy that is consistent with findings from Phase 2 and 1 trials. The trial evaluated that inclisiran was tolerated well and confirmed that its safety profile was as favorable as that shown in the ORION-3 and ORION-1 Phase 2 open-label extension studies.

Detailed safety, tolerability and efficacy data from ORION-11 would be presented at a science session being conducted at the European Society of Cardiology’s ESC Congress 2019 in Paris on the 2nd of September at 8:30 am Central European Time (CET).

Mark Timney, CEO at The Medicines Company stated that it is an important occasion that strengthens the company’s confidence on in the immense potential of inclisiran to radically change cardiovascular disease treatment.

Mark added that he was proud of the company’s clinical development department’s commitment to quickly and efficiently develop this top-quality investigational therapy which could help millions of patients of ASCVD to attain treatment goals, have healthier lives and live longer.

This global study took place at 70 different sites across seven countries, ex-U.S. Each trial participant was given inclisiran sodium 300 mg, initially given as a subcutaneous injection, then again after three months and every six months after first three months.

 

Source Credit: https://www.themedicinescompany.com/investor/pr/3992694/

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Nikita Chaurasia    

Nikita Chaurasia

Having always been daft at wordplay, Nikita Chaurasia, post the completion of post-graduation, commenced her journey into the content generation cosmos. Endowed with a professional MBA degree in Advertising and Public Relations, Nikita strives to integrate her creativ...

Read More

More News By Nikita Chaurasia

Rolls-Royce ends the salary pension scheme earlier than expected
Rolls-Royce ends the salary pension scheme earlier than expected
By Nikita Chaurasia

Reportedly, Rolls-Royce, a subsidiary of German group BMW, is planning to close its final salary pension scheme 4 years earlier to ease up pressure mounted by the grounded aircrafts. If this initiative gets a green signal from the trustees and pensi...

Scientists say COVID-19 is airborne, ask WHO to revise recommendations
Scientists say COVID-19 is airborne, ask WHO to revise recommendations
By Nikita Chaurasia

Numerous scientists across the globe have reportedly sent an open letter to WHO (World Health Organization) seeking the health agency to revise recommendations regarding the novel coronavirus. As per credible reports, around 239 scientists from 32 c...

Hyderabad gains second Oracle cloud data center after Mumbai
Hyderabad gains second Oracle cloud data center after Mumbai
By Nikita Chaurasia

American multinational computer technology corporation, Oracle has recently made it to the headlines post launching its second cloud data center in Hyderabad in a bid to support increased cloud services demand. For those uninitiated, Oracle launched...