Starpharma initiates Phase 1 study for AZD0466 using DEP® platform
Category: #health  By Mateen Dalal  Date: 2019-12-30
  • share
  • Twitter
  • Facebook
  • LinkedIn

Starpharma initiates Phase 1 study for AZD0466 using DEP® platform

Starpharma, a world leader in dendrimer product development, reportedly announced that AstraZeneca, a renowned British-Swedish biopharmaceutical company, has initiated a phase 1 clinical study of AZD0466. The first patient in this trial has been successfully administered with the drug candidate. The study would enroll patients with an array of cancers and would be conducted in 4-5 U.S. sites.

The AZD0466 development is being conducted under a multi-product license in which Starpharma is eligible to gain launch, development and sales milestones of approximately $124 million. The company is also eligible to get tiered royalties over net sales. Starpharma has received a payment of $3 million triggered from AZD0466’s first dose being administered in the phase 1 study. Under the license, AstraZeneca also finances the development expenses of DEP® AstraZeneca products.

AstraZeneca claims that AZD0466 has the capability to be a ‘best-in-class’ drug in the field. The drug has a wide opportunity in hematological (blood cancers) and solid tumors. This application of the drug is due to its ability to target both Bcl/xL and Bcl2.

Bcl2 is a medically validated oncology target having the Bcl2 inhibitor, VenclextaTM - AbbVie/Genentech (venetoclax), which was approved earlier in 2016 by the US FDA. The peak global sales were estimated to be between $2-3 billion.

Starpharma CEO, Dr Jackie Fairley stated that it is thrilling to reach this crucial milestone both for the company’s partnership with AstraZeneca as well as for Starpharma’s DEP® platform. This is the company’s first collaborated DEP® product to enter the clinic, along with the company’s three internal DEP® products, DEP® cabazitaxel, DEP® irinotecan, and DEP® docetaxel.

Fairley further added that AZD0466 is a great example of the advantages that would be created for new agents utilizing the DEP® platform and the company looks forward to new updates as the study progresses.

In August 2019, the company also observed positive outcomes for its new HER-2 focused DEP® conjugate to treat ovarian cancer.
 

Source credit: https://www.starpharma.com/news/457

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

DealerSocket closes acquisition of Auto/Mate to offer innovative DMS
DealerSocket closes acquisition of Auto/Mate to offer innovative DMS
By Mateen Dalal

DealerSocket, a customer relationship management solutions provider, has recently completed the acquisition of DMS provider Auto/Mate to offer an all-in-one innovative software for their dealerships. Auto/Mate is a leading company that develops and m...

EU and U.S. to partner to counter Huawei’s dominance on next-gen 5G
EU and U.S. to partner to counter Huawei’s dominance on next-gen 5G
By Mateen Dalal

The European Union and the United States are likely to partner to counter the increasing dominance of Chinese tech giant, Huawei Technologies on next generation 5G telecommunications technology. However, this partnership will reportedly only come int...

CytoDyn files Phase 2 basket trial for cancer antagonist Leronlimab
CytoDyn files Phase 2 basket trial for cancer antagonist Leronlimab
By Mateen Dalal

CytoDyn Inc., announced that it has submitted a Phase 2 protocol with the U.S. Food and Drug Administration (FDA) for a basket trial under its cancer IND. The company can instantly start enrollment in this trial to offer therapy for around 22 various...