Prescient expands PTX-200 trial after it eradicates cancer completely
Category: #health  By Mateen Dalal  Date: 2019-11-29
  • share
  • Twitter
  • Facebook
  • LinkedIn

Prescient expands PTX-200 trial after it eradicates cancer completely

Prescient Therapeutics, a renowned small molecule drug development firm aimed at developing new cancer therapies, reportedly announced that it is extending its Phase 1b trial in patients with AML (acute myeloid leukemia) after the disease was completely eradicated from three participating patients.

The clinical stage firm was treating 15 patients with refractory or relapsed AML using its novel drug PTX-200. Refractory or relapsed cancers are usually hard to treat as they are extremely resistant and do not respond effectively to therapy.

PTX-200 is a new PH domain inhibitor that stops a vital tumor survival pathway that is known as Akt. The Akt pathway plays a crucial role in cancer development including breast, leukemia and ovarian cancer.

PTX-200 is also being examined in an ongoing Phase 2 trial in patients with breast cancer and also in a Phase 1b study in patients with persistent platinum-resistant or recurrent ovarian cancer.

The three patients whose cancer was completely eradicated received 25-35 milligrams per square meter of PTX-200 in combination with 200 to 400 mg/m2 of cytarabine chemotherapy agent.

Dr. Terrence Chew, Chief Medical Officer at Prescient stated that these three complete responses are highly encouraging for a hard-to-treat cancer patient demographic. After it consults with study investigators, the company plans to carry out a protocol amendment to alter the PTX-200 dosing schedule in relation to the dosing of cytarabine. The change aims to minimize overlapping drug interactions. Through this protocol amendment, the company looks to get more participants through more therapy cycles with an aim to expand upon these responses.

Dr. Chew further added that the company’s investigators are highly supportive towards these amendments since they are being encouraged by the outcomes in this patient population, which is very hard to treat and presently has very few treatment options.   

Prescient further added that the amendment would go through the general FDA and ethics committee study and reviews. The company expects to re-start new patient enrolment soon in 2020.

 

Source credit: https://smallcaps.com.au/prescient-therapeutics-expands-study-completely-eradicating-cancer-in-patients/

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

DealerSocket closes acquisition of Auto/Mate to offer innovative DMS
DealerSocket closes acquisition of Auto/Mate to offer innovative DMS
By Mateen Dalal

DealerSocket, a customer relationship management solutions provider, has recently completed the acquisition of DMS provider Auto/Mate to offer an all-in-one innovative software for their dealerships. Auto/Mate is a leading company that develops and m...

EU and U.S. to partner to counter Huawei’s dominance on next-gen 5G
EU and U.S. to partner to counter Huawei’s dominance on next-gen 5G
By Mateen Dalal

The European Union and the United States are likely to partner to counter the increasing dominance of Chinese tech giant, Huawei Technologies on next generation 5G telecommunications technology. However, this partnership will reportedly only come int...

CytoDyn files Phase 2 basket trial for cancer antagonist Leronlimab
CytoDyn files Phase 2 basket trial for cancer antagonist Leronlimab
By Mateen Dalal

CytoDyn Inc., announced that it has submitted a Phase 2 protocol with the U.S. Food and Drug Administration (FDA) for a basket trial under its cancer IND. The company can instantly start enrollment in this trial to offer therapy for around 22 various...