Opthea unveils favorable results from Phase 2b wet AMD clinical trial
Category: #health  By Mateen Dalal  Date: 2019-08-08
  • share
  • Twitter
  • Facebook
  • LinkedIn

Opthea unveils favorable results from Phase 2b wet AMD clinical trial

Stable vision was achieved in 99.2% of subjects under the OPT-302 (2.0 mg) combination treatment, compared to 96.7% from the Lucentis control group at primary endpoint

Opthea Limited, a biotechnology and biopharmaceutical company that develops therapies for treatment of eye diseases, has recently announced positive results for its Phase 2b study of OPT-302 combination therapy, marking the primary endpoint of the study for the treatment of patients with wet age-related macular degeneration (AMD).

Apparently, 366 subjects with wet AMD were recruited for the Phase 2b, randomized, sham-controlled, double-masked study who were segregated in two groups, based on two different intravitreal doses of OPT-302 (0.5 mg and 2.0 mg), administered monthly along with 0.5 mg Lucentis®  over a period of 24 weeks, versus a control group that received standard monthly dose of 0.5 mg Lucentis.

Evidently, the OPT-302 combination therapy produced superior results, in terms of mean visual acuity gain at 24 weeks, compared to Lucentis® monotherapy. Subjects that received 2.0 mg dose OPT-302 combination therapy exhibited an average gain of 14.2 letters of vision on the ETDRS standardized eye chart from baseline after 24 weeks, opposed to 10.8 letters in the control group, a statistically considerable difference of 3.4 letters.

Tim Jackson, chief investigator of the trial, and Consultant Ophthalmic Surgeon at King’s College London was quoted saying that OPT-302 (2.0 mg) combination therapy yielded statistically superior results for mean visual acuity and key secondary endpoints were also supportive of the primary outcome.

Dr Pravin Dugel, managing partner of Retinal Consultants of Arizona, clinical professor at Keck School of Medicine, the University of Southern California Roski Eye Institute, and study investigator on the trial, stated that OPT-302 could potentially be a game-changer in the medicine landscape. Not only for wet AMD, but it could also cater to other devastating retinal vascular disorders that entail a significant unmet medical need for more effective treatments, he commented.

Opthea CEO and managing director Dr Megan Baldwin noted that achieving positive outcomes from the study is an enormous accomplishment and the results further assure that OPT-302 can improve patient outcomes in wet AMD.

 

Source credit: https://www.globenewswire.com/news-release/2019/08/06/1898066/0/en/Opthea-Meets-Primary-Endpoint-in-Phase-2b-Study-of-OPT-302-in-Wet-AMD.html

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

AstraZeneca to present results of Farxiga’s DAPA-CKD trial at ESC 2020
AstraZeneca to present results of Farxiga’s DAPA-CKD trial at ESC 2020
By Mateen Dalal

According to reliable sources, British-Swedish multinational pharmaceutical company AstraZeneca plc will present the much awaited results of the Phase III DAPA-CKD trial of Farxiga in CKD (chronic kidney disease) at ESC Congress 2020. Sources with r...

FDA grants Emergency Use Authorization to Abbott’s COVID-19 antigen
FDA grants Emergency Use Authorization to Abbott’s COVID-19 antigen
By Mateen Dalal

Abbott Laboratories, a U.S.-based medical devices and healthcare firm, has reportedly received the Emergency Use Authorization (EUA) from the U.S. FDA (Food and Drug Administration) for the detecting COVID-19 virus with its portable antigen test Bina...

Hyundai Wia Corp. signs gun parts export contract with BAE Systems
Hyundai Wia Corp. signs gun parts export contract with BAE Systems
By Mateen Dalal

Hyundai Wia Corp., a South Korea-based defense firm, has reportedly signed gun parts export contract with BAE Systems plc of worth USD 100 million via a pre-value accumulation system. As per the agreement, Hyundai Wia will supply over 106 types of gu...