Novartis unveils positive Phase III trial data for asthma treatment
Category: #health  By Mateen Dalal  Date: 2019-06-01
  • share
  • Twitter
  • Facebook
  • LinkedIn

Novartis unveils positive Phase III trial data for asthma treatment

Novartis has recently unveiled the first clinical trial results from the phase III PLATINUM clinical development program evaluating the efficacy and safety of QMF149, which is an investigational, once a day, fixed dose combination treatment for asthma that contains mometasone furoate and indacaterol acetate.

Sources close to the matter informed that in this randomized, multicenter, double-blind phase III QUARTZ clinical trial, once a day, low dose IND/MF 150/80 Mu g acheived the primary and also vital secondary endpoints in comparison to once a day, mometasone furoate, an ICS delivered through the Twisthaler device in both adolescent and adult patients having asthma.

Patients included in the QUARTZ clinical trial were ineffectively controlled on low dose ICS, sources mentioned.

Head of Respiratory Development Unit, Linda Armstrong, MD, said that regardless of the number of available treatments, several patients’ lives remain affected by asthma. The QMF149 results of the QUARTZ clinical trial seems to be complementing the recently released phase II data of QVM149, which was presented at the 2019 American Thoracic Society Congress.  It confirms the superiority of QVM149 to the existing standard of care.

Apparently, IND/MF statistically determined substantial improvements in lung function as measured by trough FEV1 compared to MF after 12 weeks of treatment in adolescent and adult patients with ineffectively controlled asthma. In addition, IND/MF also confirmed statistically substantial improvements in asthma control as compared to MF, when measured by ACQ-7 after 12 weeks of treatment.

Sources stated that along with this, clinically meaningful improvement in ACQ-7 is backed by a responder analysis, that showed the QMF149 group had a larger proportion of responders as compared to the MF group respectively.

Both treatments MF and IND/MF were usually well tolerated. Incidences of adverse events was overall reduced in the IND/MF group as compared to the MF group. Most adverse events in both treatment groups were mild to modest in severity and also comparable between the different treatment groups.

Source Credit: https://www.novartis.com/news/media-releases/novartis-phase-iii-quartz-study-new-investigational-inhaled-combination-treatment-qmf149-meets-primary-and-key-secondary-endpoints-patients-inadequately

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Hyundai plans to raise stake in China’s Sichuan Hyundai Motor
Hyundai plans to raise stake in China’s Sichuan Hyundai Motor
By Mateen Dalal

Hyundai Motor Company identifies the significance and impact of automobiles, and strives to fulfill its goals by creating new and advanced vehicles that addresses all the vital issues faced by drivers. The automobile giant has effectively become...

TransPerfect expands its portfolio by acquiring Sublime Subtitling
TransPerfect expands its portfolio by acquiring Sublime Subtitling
By Mateen Dalal

With decades of hard work and hands-on experience, TransPerfect has managed to become one of the largest global providers of technology and language solutions for companies worldwide. With over 5,000 global organizations employing its GlobalLink®...

Altran to launch a Digital Therapeutics Innovation Center in Boston
Altran to launch a Digital Therapeutics Innovation Center in Boston
By Mateen Dalal

Digital therapeutics are evidence-based interventions conducted by advanced software programs to manage, treat or prevent clinical disorders. Its adoption has augmented the whole medical industry, making it simpler for practitioner to ...