GlaxoSmithKline presents the PRIMA study for first-line ovarian cancer
Category: #health  By Mateen Dalal  Date: 2019-09-30
  • share
  • Twitter
  • Facebook
  • LinkedIn

GlaxoSmithKline presents the PRIMA study for first-line ovarian cancer

The treatment graph for one of the most fatal ailments of the 21st century, the dreaded ‘cancer’, seems to be on the verge of witnessing yet another variable addition. In what may seem as yet another stupendous effort by healthcare companies and the like to cure one of the deadliest diseases known to mankind, the results for yet another clinical study have been announced by a prominent organization.

Recently, biopharma company Zai Lab Limited made it to the headlines by announcing the results of its partner, GlaxoSmithKline’s, PRIMA. Incidentally, PRIMA is a randomized, double-blind, placebo-controlled Phase 3 study of Zejula (niraparib) as maintenance therapy in women who are suffering from first-line ovarian cancer, following a response to platinum-based chemotherapy. According to reports, there is reduced 38% disease progression risk or death in the overall population because of niraparib treatment.

PRIMA is the first study which demonstrates, a PARP inhibitor that significantly improves PFS, regardless of biomarker status.

There is a meaningful reduction in risk of progression in the women who are suffering from BRCA mutation tumors, HR-deficient BRCA wild type tumors, and HR-proficient tumors.

This study registered response of patients to first-line platinum-based chemotherapy treatment which also includes patients with a high risk of disease progression.

In an interim assessment of overall survival (OS), niraparib also showed an encouraging improvement in overall survival relative to placebo. A pre-scheduled interim analysis of overall analysis statically favored niraparib in the overall population. On niraparib, 91% of patients were alive at 24 months against 85% for placebo, in HR-deficient group.

However, the authenticity of this data is not fully known. The analysis also showed 81% of women on niraparib were alive at 24 months against 59% of women receiving placebo, in HR deficient group.

Currently, Niraparib is not approved as a treatment for first-line ovarian cancer. GSK will be sharing these data with the relevant health authorities.

Dr. Hal Barron, President, and Chief Scientific Officer R&D stated that Ovarian cancer is the eighth most commonly occurring disease in women. PRIMA is a landmark study in this context, as the company believes that this data has the potential to change ovarian cancer treatment landscape.

Source Credit - https://zailab.gcs-web.com/news-releases/news-release-details/phase-3-prima-trial-zejular-niraparib-first-stud  y-show-parp-0

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

NHS requests urgent donations of blood plasma from COVID-19 survivors
NHS requests urgent donations of blood plasma from COVID-19 survivors
By Mateen Dalal

According to reliable sources, United Kingdom National Health Service (NHS) has filed an appeal to the individuals recuperated from novel coronavirus to donate blood plasma. The organization apparently intends to treat the people who get infected dur...

OSE Immunotherapeutics receives $228,000 to develop COVID-19 vaccine
OSE Immunotherapeutics receives $228,000 to develop COVID-19 vaccine
By Mateen Dalal

The novel coronavirus outbreak has turned out to be one of the worst disasters the world has witnessed in recent times. At times like this, pharmaceutical companies worldwide have been putting their best foot forward to find the vaccine for COVID-19....

Singapore’s ESR and Sabana REIT propose merger amid pandemic
Singapore’s ESR and Sabana REIT propose merger amid pandemic
By Mateen Dalal

Although the economic impact of the ongoing COVID-19 has significantly impacted prospects for Singapores REITs (Real Estate Investment Trusts), it seems that some resilient spots in the real estate sector will remain where they were. In the latest st...