Galapagos begins Phase 1 trial for second generation Toledo compound
Category: #health  By Mateen Dalal  Date: 2019-09-26
  • share
  • Twitter
  • Facebook
  • LinkedIn

Galapagos begins Phase 1 trial for second generation Toledo compound

Cases of inflammatory diseases are expected to increase in the near future, which is a major concern for people across the world. Various pharmaceutical companies as well as medical research organizations are increasingly working towards finding novel solutions for these ailments owing to the growing demand for inflammatory disease treatments.    

Galapagos NV, a Belgo-Dutch pharmaceutical company headquartered in Mechelen, Belgium, reportedly announced that it has started Phase 1 trial with a second-generation compound, GLPG3970, against an undisclosed and novel inflammation target class that was discovered by the company itself.

The Toledo platform delivers tiny molecule inhibitors of the Toledo targets with selectivity profiles that are different. GLPG3970 is a more selective, second-generation compound whose preclinical activity has been observed already in several inflammatory indications, which includes inflammatory bowel diseases, psoriasis and rheumatoid arthritis.

The Phase 1 clinical trial is a placebo-controlled, double-blind study that would evaluate the tolerability, safety, efficacy, as well as PK/PD1 of GLPG3970 single as well as multiple ascending doses in over 52 healthy male adults, and in the next step, in about 20 psoriasis patients.

The Phase 1 trial with the company’s first-gen Toledo compound, GLPG3312, was announced by the company in early 2019, with its outcomes expected early in 2020. The Phase 2 study in patients with ulcerative colitis is scheduled to begin in H1 2020.

Chief Scientific Officer at Galapagos, Dr. Piet Wigerinck stated that the company is thrilled with the quick progress of its second Toledo compound in the clinic. With the initiation of this trial, the company is on track to launch multiple concept studies’ proof in parallel with full potential next year, in a series of inflammatory diseases.

Wigerinck further added that Toledo program is capable of becoming a novel paradigm in inflammatory diseases treatment because of its unique action mechanism.

Earlier in August, Gilead Sciences, Inc. and Galapagos NV announced closing of global development and research collaboration which was inked on 14 July 2019. The agreement had received clearance under Hart-Scott-Rodino Antitrust Improvements Act 1976 from the U.S. Federal Trade Commission as well as Austrian Federal Competition Authority’s merger control approval.

The aforementioned agreement was inked to maximize innovation based on the development of new mode-of-action medicines.
 

Source credit: https://www.glpg.com/press-releases

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Alphabet’s Google to face lawsuit from NLRB for violating labor laws
Alphabet’s Google to face lawsuit from NLRB for violating labor laws
By Mateen Dalal

In a recent turn of events, U.S. government body National Labor Relations Board (NLRB) has reportedly issued a complaint against American multinational technology company, Google LLC for unlawfully monitoring as well as questioning its workers and su...

Britain’s CMA to levy tougher competition rules on Google and Facebook
Britain’s CMA to levy tougher competition rules on Google and Facebook
By Mateen Dalal

Facebook and Google accounted for around 80% of the total 14 billion pounds spent on digital advertising in 2019. MOW has reportedly accused Google of modifying its Chromium developer tools and Chrome browser to get greater control over advertiser...

Amazon, U.S. Government team up to prevent sale of counterfeit goods
Amazon, U.S. Government team up to prevent sale of counterfeit goods
By Mateen Dalal

According to reliable sources, Washington-headquartered American multinational technology company, Amazon.com Inc has reportedly initiated a joint venture with the U.S. government’s counterfeit agency, the IPR Center (National Intellectual Prop...