Cyclacel unveils Phase 1 clinical data for its breast cancer treatment
Category: #health  By Mateen Dalal  Date: 2019-04-02
  • share
  • Twitter
  • Facebook
  • LinkedIn

Cyclacel unveils Phase 1 clinical data for its breast cancer treatment

·         The data was presented at the American Association for Cancer Research Annual Meeting 2019

·         There were substantial responses and stable disease in PARP inhibitor naïve patients

Cyclacel Pharmaceuticals, Inc., a biopharmaceutical company which develops innovative medicines related to cancer cell biology has reportedly announced Phase 1 clinical data for itss DNA damage response program with a sequential and oral regimen of seliciclib and sapacitabine as a treatment for BRCA mutant metastatic breast cancer patients.

According to Cyclacel, the data presented at the AACR Annual Meeting 2019 described that the regimen was safe and showed a clinical benefit rate of 30%. In addition, the 8 PARP inhibitor naïve patients, of which half of the them were treated previously by platinum agents and one on earlier PARP inhibitors showed responses. Progression on PARP inhibitors or previous platinum was related to lack of benefits.

Apparently, both PARP inhibitors and sapacitabine are more productive in cancer cells exhibiting BRCA mutations, besides any other homologous recombination repair deficiency. The investigators, based on these data, are conducting a Phase 1b/2 trial of sapacitabine in combination with a PARP impediment in PARP inhibitor naïve BRCA mutant breast cancer patients.

Sara Tolaney, MD, MPH, Senior Physician, Principal Investigator of the study mentioned that the company officials have gained confidence by the substantial responses as well as stable disease in the PARP inhibitor naïve patients having BRCA breast cancer.         

The studies supposedly evaluated a sequential and oral regimen of a nucleoside analog prodrug, sapacitabine, and seliciclib, which is a 1st generation CDK2/9 inhibitor, in patients having metastatic breast cancer fostering BRCA ½ mutations.

Under this trial, patients received 7 days of sapacitabine which is followed by 3 days of seliciclib. Total 20 patients were treated, seven of which progressed on prior PARP inhibitor and six progressed on prior platinum therapy.

Sapacitabine (CYC682) is allegedly one of the orally available nucleoside analogues which acts through a novel DNA single-strand breaking mechanism that leads to production of DSBs and checkpoint activation.

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Apple intends to inaugurate its new $1Bn campus in Texas by 2022
Apple intends to inaugurate its new $1Bn campus in Texas by 2022
By Mateen Dalal

The U.S – China trade war has been terrorizing the global economy since the dawn of 2018. It has affected the overall financial market and global supply chains. This ongoing trade war has had a negative impacted U.S. tech giant Apple’s sh...

Salesforce to use Amazon’s cloud to enhance call center services
Salesforce to use Amazon’s cloud to enhance call center services
By Mateen Dalal

Salesforce will use Amazon Web Services’ technology to turn customer’s spoken words into text.   The partnership will bring Amazon and Salesforce into more direct competition with call center technology service providers. Sales...

FDA warns Dollar Tree regarding the sale of imported adulterated drugs
FDA warns Dollar Tree regarding the sale of imported adulterated drugs
By Mateen Dalal

FDA’s new warning letter is asking Dollar Tree to ensure the company does not import adulterated medicines   Manufacturers mentioned in the letter include Hangzhou Zhongbo and Shanghai Weierya Daily Chemicals Reports confirm that the...