Context Therapeutics begins Phase 2 Apristor trial for cancer patients
Category: #health  By Mateen Dalal  Date: 2019-05-04
  • share
  • Twitter
  • Facebook
  • LinkedIn

Context Therapeutics begins Phase 2 Apristor trial for cancer patients

The latest study will assess Apristor’s safety plus pharmacological profile in patients, besides the biomarker analyses, for exploring the drug’s predictive response factors.

Context Therapeutics, a U.S.-based clinical stage biopharmaceutical company, has reportedly announced a Phase 2 trial for studying the safety and efficacy of Apristor® (onapristone extended release) in patients with advanced gynecological tumors and are PgR+ (progesterone receptor positive). Context will conduct the study in close collaboration with the world-leading MSKCC (Memorial Sloan Kettering Cancer Center), whose MD, Rachel N. Grisham, is the Prime Investigator of the study.

According to reliable sources, the Phase 2 trial will be including patients with different PgR+ solid tumors at advanced stages, that include low grade serous ovarian cancer, granulosa cell tumor and endometrioid endometrial cancer, who have also sought prior chemotherapy treatment. Apristor will be evaluated in around 84 cancer patients, with the primary endpoint to be the ORR (overall response rate). Sources added that the secondary endpoints, for further characterizing Apristor’s activity, will include clinical benefit rate, response duration and PFS (progression-free survival). The preliminary trial results are expected by mid-2020.

Tarek Sahmoud, M.D., Ph.D., the Chief Medical Officer at Context Therapeutics, was quoted stating that there is availability of limited therapeutic options at present for treating these cancers within an advanced setting. Apristor is promising to help treat women with the PgR+ gynecological cancers, given the recent preclinical findings, along with the Phase 1 study outcomes. He went on to comment that Apristor has the potential to make an impactful difference for patients enrolled in the trial. 

For the record, Apristor is a new investigational drug – an orally administered, complete progesterone receptor antagonist. In the recent Phase 1 trial, the drug exhibited clinical benefits and was well tolerated in patients suffering from PgR+ ovarian, endometrial and breast cancer. As per preclinical data, Apristor’s anticancer activity helps block the activation of progesterone receptor signaling with mitogenic growth factors, inhibits mammosphere formation and downregulates gene signatures linked with cancer stem cell mobilization & metastasis.

Source Credits: https://www.businesswire.com/news/home/20190502005076/en/Context-Therapeutics-World-Renowned-Cancer-Center-Announce-Phase

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

AstraZeneca to present results of Farxiga’s DAPA-CKD trial at ESC 2020
AstraZeneca to present results of Farxiga’s DAPA-CKD trial at ESC 2020
By Mateen Dalal

According to reliable sources, British-Swedish multinational pharmaceutical company AstraZeneca plc will present the much awaited results of the Phase III DAPA-CKD trial of Farxiga in CKD (chronic kidney disease) at ESC Congress 2020. Sources with r...

FDA grants Emergency Use Authorization to Abbott’s COVID-19 antigen
FDA grants Emergency Use Authorization to Abbott’s COVID-19 antigen
By Mateen Dalal

Abbott Laboratories, a U.S.-based medical devices and healthcare firm, has reportedly received the Emergency Use Authorization (EUA) from the U.S. FDA (Food and Drug Administration) for the detecting COVID-19 virus with its portable antigen test Bina...

Hyundai Wia Corp. signs gun parts export contract with BAE Systems
Hyundai Wia Corp. signs gun parts export contract with BAE Systems
By Mateen Dalal

Hyundai Wia Corp., a South Korea-based defense firm, has reportedly signed gun parts export contract with BAE Systems plc of worth USD 100 million via a pre-value accumulation system. As per the agreement, Hyundai Wia will supply over 106 types of gu...