Cellectis reveals POC for smart T-cells that recognize tumors
Category: #health  By Mateen Dalal  Date: 2019-11-15
  • share
  • Twitter
  • Facebook
  • LinkedIn

Cellectis reveals POC for smart T-cells that recognize tumors

Cellectis, a French biopharmaceutical company that aims to innovate immunotherapies based on gene-edited allogeneic CAR T-cells, recently revealed a report issued in Nature Communications that explains a proof-of-concept (POC) for cell pathway’s rewiring to produce extremely intelligent T-cells which could identify cancerous tumors and create a micro secretion of therapeutic proteins.

This advancement could eventually enhance the capability of T-cells to fight cancer and redesign the tumor microenvironment. Moreover, by using gene editing procedures to rewire the CD25, PD1 and TCRα genes, the study allowed CAR T-cells to micro secrete the IL-12, pro-inflammatory cytokine, in a tumor.

Reportedly, this procedure was done in a time-dependent manner which would further lay the foundation for the next generation of highly active, potentially safer and tightly controlled CAR T-cell therapies.

Speaking on the move, Dr. Philippe Duchateau, Ph.D., Chief Scientific Officer, Cellectis, said that the conversation near the tumor microenvironment has become a trending issue in the CAR T-cell space, and with the current developments in gene-editing technologies, particularly TALEN®, has opened the possibility to manipulate T-cell’s way to regulate itself to adjust with its environment.

Duchateau added that, with successively rewiring their natural regulatory activities and seamless modification of various genes, this method would trigger T-cells to produce therapeutic proteins of interest in a strongly localized and controlled manner. 

Additionally, the company has changed the current T-cells into powerful and precise micro-robots which could spray IL-12 precisely onto cancer cells. This would prevent the potential toxicity of IL-12’s systemic injection while improving CAR-T activity.

Earlier this year, Cellectis had made headlines when it revealed that it has signed a manufacturing service agreement that covers clinical manufacturing of the company’s allogeneic UCART drug candidates pursuing hematological malignancies. 

Reportedly, the manufacturing is expected to be conducted at Lonza's GMP facility which is located in Geleen, Netherlands.

Source Credit: https://www.cellectis.com/en/press/cellectis-publishes-creation-of-smart-car-t-cells-for-potentially-safer-more-effective-treatments-for-cancer-in-nature-communications/

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Wipro recognized as global leader in Software Defined Network Systems
Wipro recognized as global leader in Software Defined Network Systems
By Mateen Dalal

Wipro has established a strong name as a key WAN services provider. Rising star in SD Network Security Services and SDN Transformation Services, claims report. The network delivery is managed through a wide variety of products, processes, and too...

Microsoft to fix an active security flaw in Internet Explorer
Microsoft to fix an active security flaw in Internet Explorer
By Mateen Dalal

Microsoft, the renowned American tech giant, reportedly verified the presence of a security flaw that is affecting Internet Explorer (IE) and is being used by hackers. The company also said it is working to find a fix for this bug, which would be rel...

Dermtech signs a commercial & medicare advantage coverage agreement
Dermtech signs a commercial & medicare advantage coverage agreement
By Mateen Dalal

DermTech Inc., a San Diego based biotechnology company that is involved in precision dermatology, has recently announced signing a contract with a regional health plan to develop its gene expression based PLA (Pigmented Lesion Assay) for prior detect...