Assembly Biosciences reveals data from Phase 2a studies of ABI-H0731
Category: #health  By Mateen Dalal  Date: 2019-04-15
  • share
  • Twitter
  • Facebook
  • LinkedIn

Assembly Biosciences reveals data from Phase 2a studies of ABI-H0731

The data received to date is directionally correct and reduction in HBeAg and HBsAg have been observed in some individuals in both studies.

U.S. based clinical-stage biotechnology firm, Assembly Biosciences, Inc. has recently revealed interim outcomes from its two Phase 2a clinical trials of ABI-H0731 (731), a new antiviral in development targeted for the treatment of chronic HBV infection.

Reportedly, the data was presented during a late-breaker oral presentation at the International Liver Congress™(ILC), the EASL’s (European Association for the Study of the Liver) annual conference in Vienna, Austria.

According to reports, the oral presentation assessed interim analyses from two current double-blind, placebo-controlled Phase 2a reports of 731 in HBV subjects assessing the potential benefit of combination with SOC (standard of care) nucleos(t)ide (Nuc) therapy.

Reportedly, the studies explore the first two critical steps assumed to be necessary for a direct acting antiviral therapy to attain higher cure rates, including the capability to eliminate residual viremia and avert new viral replication, and the prevention of new cccDNA generation.

In addition, interim analyses suggest deeper and faster declines in HBV RNA and HBV DNA are possible with combination therapy.

According to a statement, Dr. Jacob Lalezari, Quest Clinical Research, San Francisco, said that the interim analysis of two Phase 2a studies validate that 731 in combination with Nuc therapy demonstrates fast and improved anti-HBV activity. He said that the data they have seen so far are directionally correct and reduction in HBsAg and HBeAg have been detected in some individuals in both studies.

Speaking on the outcomes, Derek Small, President & CEO, Assembly Biosciences, said that the company’s 730 combination interim data validate the potential of core inhibitors along with Nuc therapy to be the mainstay of HBV cure regimes going forward.

He said the firm is encouraged by the tolerability, safety and initial antiviral activity it has seen till date from the Nuc combination and core inhibitor and is looking forward to results throughout the year following longer-term treatment.

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Airbus cuts back production of jets amid rising COVID-19 concerns
Airbus cuts back production of jets amid rising COVID-19 concerns
By Mateen Dalal

Aircraft manufacturer Airbus is reportedly set to reduce jet plane production by a third. This decision has been taken considering the possibility of further impact on the global aviation industry by the coronavirus epidemic, even after the easing of...

AIVITA declares updates for AV-GMB-1 clinical trial in GBM patients
AIVITA declares updates for AV-GMB-1 clinical trial in GBM patients
By Mateen Dalal

AIVITA Biomedical, Inc., a biotech firm developing innovative cell therapies, has recently announced updates to the survival data after the year-end analysis of the ongoing AV-GBM-1 Phase 2 clinical trial in newly diagnosed glioblastoma (GBM) patient...

Lufthansa to shut down Germanwings & de-commission over 40 aircrafts
Lufthansa to shut down Germanwings & de-commission over 40 aircrafts
By Mateen Dalal

Lufthansa, the flag carrier and largest German airline, is reportedly shutting down its Germanwings, a low-cost airline, due to the rising impact of coronavirus on the business. The airline is also planning to de-commission over 40 aircrafts due to t...