Adverum presents data from OPTIC Phase 1 study of ADVM-022
Category: #health  By Mateen Dalal  Date: 2020-01-13
  • share
  • Twitter
  • Facebook
  • LinkedIn

Adverum presents data from OPTIC Phase 1 study of ADVM-022

Adverum Biotechnologies, Inc., a U.S. based biotechnology company that develops innovative therapies for ocular and rare diseases, has announced its first patient data from the OPTIC phase 1 clinical study of ADVM-022, an intravitreal injection gene therapy for wet age-related macular degeneration (AMD).

Reportedly, Charles C. Wykoff M.D., Ph.D., director of research, Retina Consultants of Houston, presented the data at New York’s Atlantic Coast Retina Club Macula 20/20 annual meet.

As per a recent report, ADVM-022 was seen to remain well-tolerated among the first cohort with no signs of procedure-related or drug-related serious adverse events (SAEs), no adverse events fulfilling the conditions for dose-limiting toxicities (DLTs) and no drug-related systemic adverse events.

However, six patients in the trial suffered from low-grade inflammation which was mostly moderate to mild and was responsive to steroid eye drops. Moreover, one particular ocular SAE, retinal detachment, was reported that was not related to the administration procedure or ADVM-022.

According to a statement, Aaron Osborne, MBBS, Chief Medical Officer, Adverum, said that these latest findings are promising as they carry on supporting the efficacy, durable and safety clinical profile of the drug.

The therapy has the potential to alter the treatment paradigm for patients suffering from wet AMD. The current standard of care, anti-VEGF injections, possess a substantial treatment burden and real-world findings data indicate that vision outcome is suboptimal because of undertreatment.

Osborne claims that in the company’s OPTIC’s first cohort it continues to observe anatomical improvements and stable vision being retained out to an average of 44 weeks after one ADVM-022 injection in these hard-to-treat subjects who earlier needed regular anti-VEGF injections.

Adverum is looking forward to delivering longer-term findings from the 24-week data from the second cohort and initial cohort of OPTIC at the Exudation, Angiogenesis and Degeneration 2020 symposium, said Osborne.

Source Credit: http://investors.adverum.com/news-releases/news-release-details/adverum-biotechnologies-reports-additional-clinical-data-first-0

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More

More News By Mateen Dalal

Alphabet’s Google to face lawsuit from NLRB for violating labor laws
Alphabet’s Google to face lawsuit from NLRB for violating labor laws
By Mateen Dalal

In a recent turn of events, U.S. government body National Labor Relations Board (NLRB) has reportedly issued a complaint against American multinational technology company, Google LLC for unlawfully monitoring as well as questioning its workers and su...

Britain’s CMA to levy tougher competition rules on Google and Facebook
Britain’s CMA to levy tougher competition rules on Google and Facebook
By Mateen Dalal

Facebook and Google accounted for around 80% of the total 14 billion pounds spent on digital advertising in 2019. MOW has reportedly accused Google of modifying its Chromium developer tools and Chrome browser to get greater control over advertiser...

Amazon, U.S. Government team up to prevent sale of counterfeit goods
Amazon, U.S. Government team up to prevent sale of counterfeit goods
By Mateen Dalal

According to reliable sources, Washington-headquartered American multinational technology company, Amazon.com Inc has reportedly initiated a joint venture with the U.S. government’s counterfeit agency, the IPR Center (National Intellectual Prop...